Re-polarisation of Macrophages Within Collective Tumour Cell Migration: A Multiscale Moving Boundary Approach

Cancer invasion of the surrounding tissue is a multiscale process collective cell movement that involves not only tumour cells but also other immune in environment, such as tumour-associated macrophages (TAMs). The heterogeneity these cells, with two extremes being pro-inflammatory and anti-tumour M1 anti-inflammatory pro-tumour M2 has significant impact on cancer interact different ways ExtraCellular Matrix (ECM). Experimental studies have shown co-migrate TAMs, TAM sub-populations (which can change their phenotype re-polarise depending microenvironment) this co-migration fully understood. In study, we extend previous multi-scale moving boundary mathematical model, by introducing M1-like alongside exerted effects process. With help model investigate numerically re-polarising TAMs into anti-tumoral how strategy affects overall progression. particular, whether M2?M1 re-polarisation could depend time and/or space, what would be macroscopic spatial- temporal-dependent invasion.